Advanced® Model 4250 Single-Sample Cryoscope

cryoscopeAdvanced® Model 4250 Single-Sample Cryoscope for Added Water Determination in Milk

The Advanced Instruments Model 4250 Single-Sample Cryoscope employs the freezing point depression (FPD) method for the determination of added water in milk.

Single sample, 2.0 or 2.5 ml sample size, the Model 4250 Cryoscope design includes m°C or m°H scale, timed plateau or plateau seeking modes, and multi-language display prompts. A frost-free cooling chamber eliminates most routine maintenance. Additionally, the 4250 sample probe and stir-wire are fully accessible for easy cleaning.

  • On-board printer
  • Automated calibration
  • Simple push-button design
  • Multi-language capabilities
  • Statistical analysis
  • Stores up to 30 test results
  • Optional bar code scanner

The Model 4250 allows your plant to manage a premium milk supply, ensure quality products and improve your operating efficiency. The 4250 offersboth the International Reference and screening freezing point methods for rapid, precise, reliable results.

Advanced Instruments also supplies CryoLine, NIST-traceable quality supplies for use with our Cryoscopes.

  • 422 and 621 Milk Calibration Standards
  • Lactrol® 530 Reference Solution
  • Specifically designed to satisfy ISO, HACCP, and QA/QC requirements
  • Helps assure monitoring and control of milk supply process and product integrity, from farm to finished product

Advanced® Model 4250 Single-Sample Cryoscope Technical Specifications


Power Requirement: 100 to 130 VAC (50/60 Hz) or 200 to 250 VAC (50/60 Hz)
Fuses (2): 250V time delay (Type T): 2-Amp (100-130 VAC); 1-Amp (200-250 VAC)
Power Consumption: 150 Watts
Memory Backup: Integral lithium cell; 10-year life (typical); (not user replaceable)

Sample Volume

2.0 to 2.5 mL

Sample Capacity

Single sample


20-character vacuum fluorescent display


mºC or mºH


0 to 1000 mºC or mºH


1 mºC or mºH


On-board printer, DTE EIA-232/V.24 (RS-232) serial port and optional barcode scanner

Performance at Reference Conditions


Less than 0.5% from a straight line


± 2 mºC or mºH (1 S.D.) between 0 and -400 mºC ± 0.5% (1 S.D.) between -400 and -1000 mºC


Less than 1 unit per month

Performance Over Operating Conditions

Temperature Effects

Less than 1 unit for every 5°C (9°F) ambient temperature change.

Operating Conditions Temperature

18°C to 35°C (64°F to 95°F)


5 to 80% relative humidity (non-condensing)

Storage Temperature

-40°C to +45°C (-40°F to +113°F)

Start-up Time

Immediately from stand-by; under 5 minutes from power-on

Test Time

Approximately 90 seconds in 30-second timed mode


30.5 cm x 33.0 cm x 45.7 cm
(12.0” H x 13.0” W x 18.0” D)
Height With Head Up: 40.6 cm (16.0” H)


Net: 12.7 kg (28.0 lbs.)
Shipping: 17.7 kg (39.0 lbs.)


One-year limited warranty on workmanship and all parts except glass, plastic, and parts warranted by their makers


This product is a certified CE and ETL-USA instrument

Installation Class: I

Category: II
Pollution Degree: 2
Moisture Protection: IPX0 (ordinary)